ABSTRACT
Burkholderia cepacia is a beta proteobacterium multidrug-resistant Gram-negative pathogen. At least nine different species cause infections in people with chronic granulomatous disease and cystic fibrosis (CF). In this report, we focused on Bcc that caused thyroiditis in people. Isolates were collected from patients with thyroiditis for complete genome sequencing. The sequencing results were 352 contigs, an estimated genome length of 23,628,288 bp, and an average G+C content of 59.99%.
ABSTRACT
Introduction: Mild course COVID-19 patients are mostly managed at home and need next to correct medication appropriate techniques to deal with their symptoms. Methods: A 23-year old male performed self-administered Eurythmy Therapy exercises during 14 days quarantine and afterwards in rehabilitation. Results: The patient reported positive effect in terms of relaxation or vitalization of Eurythmy Therapy exercises on COVID-19 symptoms: headache, fatigue, dsypnoea, chest pain, body tension and asthenia. Discussion/Conclusion: Eurythmy Therapy exercises might be helpful managing COVID-19 symptoms and can be applied on a self-help basis.
ABSTRACT
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic is a threat to ongoing clinical trials necessitating regular face-to-face, in-person meetings, particularly in participants with a high risk of complications. Guidance on how to handle and safely continue such trials is lacking. Chronically ill elderly individuals require-in addition to protection from infection-regular physical exercise and social contact to remain healthy. Solutions on how to handle these conflicting necessities are needed. The ENTAIER-randomised controlled trial was investigating the influence of mindful movements on fall risk, fear of falling, mobility, balance, life quality, and other outcomes. The study population was planned to comprise of 550 chronically ill elderly individuals with a high risk of falling. The movements were regularly performed in coached groups over 6 months. After the trial began, COVID-19 lockdowns stopped all in-person meetings, and it was expected that the limitations of this pandemic would continue for a long term. Therefore, the exercise programme, which involved complex movements and was typically conducted face-to-face in groups, had to be substituted by a telemedicine programme within a short timeframe. The objectives, therefore, were to identify challenges and tasks that could to be resolved and steps that could to be taken to achieve high-quality, efficacy, safety, and enable human encounter and motivation. METHODS: We proceeded with four steps: 1) A literature review on the quality and feasibility issues of telemedicine in general, and specifically, in exercise training in elderly individuals. 2) Participation in two international telemedicine task forces on integrative medicine, particularly, mind-body medicine. 3) Interviews with study therapists, (for practical purposes, eurythmy therapists and Tai Chi teachers are summarized here as therapists) personnel, and international experts on providing mindful movement exercises and other physiotherapies via live telecommunication technology, and with scientists and patient representatives. 4) Final evaluation by the core trial team and subsequent planning and implementation of changes in the trial organisation. RESULTS: Various tasks and challenges were identified: for the technical equipment for therapists and patients; for the ability of therapists and trial participants to adequately manage the technology and telemedicine intervention; the reservations and concerns about the technology among therapists and participants; safety and data protection in using the technology; and study design. The two major options found on how to continue the trial in the COVID-19 situation were a complete switch to telemedicine and a partial switch in the form of risk management implemented into the former design. CONCLUSIONS: The management of an ongoing clinical trial in a national or international crisis with a minimum of available time and extra financial resources, alongside with two checklists on steps and procedures for trial continuation and telemedicine implementation, may be informative for other researchers or healthcare providers faced with similar challenges and making similar decisions in the current situation or similar future scenarios. TRAIL REGISTRATION: www.drks.de . DRKS00016609. Registered July 30, 2019.